The rapid increase of industry-sponsored clinical research towards developing countries has led to potentially complex ethical issues to assess. There is scarce evidence about the perception of these participants about the ethical compliance, security, and protection. We sought to evaluate and contrast the awareness and perception of participants and non-participants of industry-sponsored research trials on ethical, safety, and protection topics. A Cases-control survey conducted at twelve research sites in México. Previous and current participants of ISRT as well as non-participants with (...) one of four chronic diseases, were asked to complete the survey which focused on ethical compliance and protection issues of ISRT, and the perception of participating in a trial. A total of 604 cases and 604 controls were surveyed. Cases significantly answered that ethics committees are aware of what is happening in studies, and that medical care of industry-sponsored research trials is better than their usual medical care. The same proportion of cases and controls thought patients must receive economical reimbursement for participating in a research study. The informed consent of the pharmaceutical clinical trial was fully read by 90.4% of the cases. Most cases were satisfied or very satisfied with their overall study participation. Previous and current participants of industry-sponsored research trials have a more positive attitude towards ethics committees, the quality of medical care of the research trials, and the main purpose of economical reimbursements, when compared to non-participants. (shrink)

The health emergency due to the COVID-19 pandemic revealed limitations in health systems worldwide, making it necessary to establish a bioethical framework that provides tools to drive health professionals’ decision-making amid scarce health resources. Bioethical models such as principlism, utilitarianism, and personalism seek to focus clinical decisions on respect for people’s rights and dignity, thus protecting the medical practice. Personalism provides a person-centered approach to respect for human dignity during health emergencies to avoid giving material meaning to the individual. Decision (...) criteria are required to face bioethical conflicts in clinical practice, reducing the legal, emotional, and ethical burden of decision-making in pandemic situations. (shrink)

This article reads some familiar examples of contemporary visual arts, such as Cindy Sherman, Mona Hatoum, Robert Gober, John Miller, Eva Hesse, Orlan and Robert Mapplethorpe, by engaging with diff...

This book seeks to arrive at a better understanding of the relationships between the objective and subjective aspects of time. It discusses the existence of fluent time, a controversial concept in many areas, from philosophy to physics. Fluent time is understood as directional time with a past, a present and a future. We experience fluent time in our lives and we adopt a temporal perspective in our ways of knowing and acting. Nevertheless, the existence of fluent time has been debated (...) for both philosophical and scientific reasons, thus creating a rift between the subjective and objective aspects of time. Starting from the basic notion of points of view, or perspectives, this book explores the relationships between objective or external time, as it has been conceptualized by science, and subjective or internal time, which is involved in our lived experiences. It establishes a general framework encompassing the nature, structure and mode of existence of points of view, in which the objective and subjective aspects of time can be integrated. The book mainly addresses researchers and postgraduates in philosophy and logic. Additionally, it offers inspiration for physicists and computer scientists involved in the modeling and simulation of complex behaviors for which the representation of internal time should be considered together with the notion of objective, external time. (shrink)

Background As our society is ageing, nursing homes are finding it increasingly difficult to deal with an expanding population of patients with dementia and a decreasing workforce. A potential answer to this problem might lie in the use of technology. However, the use and application of surveillance technology in dementia care has led to considerable ethical debate among healthcare professionals and ethicists, with no clear consensus to date. Aim To explore how surveillance technology is viewed by care professionals and ethicists (...) working in the field, by investigating the ideal application of surveillance technology in the residential care of people with dementia. Methods Use was made of the concept mapping method, a computer-assisted procedure consisting of five steps: brainstorming, prioritising, clustering, processing by the computer and analysis. Various participants (ranging from ethicists to physicians and nurses) were invited on the basis of their professional background. Results The views generated are grouped into six categories ranging from the need for a right balance between freedom and security, to be beneficial and tailored to the resident, and clearly defined procedures to competent and caring personnel, active monitoring and clear normative guidance. The results are presented in the form of a graphic chart. Conclusions There appears to be an inherent duality in the views on using surveillance technology which is rooted in the moral conflict between safety and freedom. Elaboration of this ethical issue has proved to be very difficult. (shrink)

A current issue in psycholinguistic research is whether the language difficulties exhibited by children with developmental language disorder [DLD, previously labeled specific language impairment ] are due to deficits in their abilities to pick up patterns in the sensory environment, an ability known as statistical learning, and the extent to which explicit learning mechanisms can be used to compensate for those deficits. Studies designed to test the compensatory role of explicit learning mechanisms in children with DLD are, however, scarce, and (...) the few conducted so far have led to inconsistent results. This work aimed to provide new insights into the role that explicit learning mechanisms might play on implicit learning deficits in children with DLD by resorting to a new approach. This approach involved not only the collection of event-related potentials, while preschool children with DLD [relative to typical language developmental controls] were exposed to a continuous auditory stream made of the repetition of three-syllable nonsense words but, importantly, the collection of ERPs when the same children performed analogous versions of the same auditory SL task first under incidental and afterward under intentional conditions. In each of these tasks, the level of predictability of the three-syllable nonsense words embedded in the speech streams was also manipulated to mimic natural languages closely. At the end of both tasks’ exposure phase, children performed a two-alternative forced-choice task from which behavioral evidence of SL was obtained. Results from the 2-AFC tasks failed to show reliable signs of SL in both groups of children. The ERPs data showed, however, significant modulations in the N100 and N400 components, taken as neural signatures of word segmentation in the brain, even though a detailed analysis of the neural responses revealed that only children from the TLD group seem to have taken advantage of the previous knowledge to enhance SL functioning. These results suggest that children with DLD showed deficits both in implicit and explicit learning mechanisms, casting doubts on the efficiency of the interventions relying on explicit instructions to help children with DLD to overcome their language difficulties. (shrink)

From an early age, exposure to a spoken language has allowed us to implicitly capture the structure underlying the succession of speech sounds in that language and to segment it into meaningful units. Statistical learning, the ability to pick up patterns in the sensory environment without intention or reinforcement, is thus assumed to play a central role in the acquisition of the rule-governed aspects of language, including the discovery of word boundaries in the continuous acoustic stream. Although extensive evidence has (...) been gathered from artificial languages experiments showing that children and adults are able to track the regularities embedded in the auditory input, as the probability of one syllable to follow another syllable in the speech stream, the developmental trajectory of this ability remains controversial. In this work, we have collected Event-Related Potentials while 5-year-old children and young adults were exposed to a speech stream made of the repetition of eight three-syllable nonsense words presenting different levels of predictability to mimic closely what occurs in natural languages and to get new insights into the changes that the mechanisms underlying auditory statistical learning might undergo through the development. The participants performed the aSL task first under implicit and, subsequently, under explicit conditions to further analyze if children take advantage of previous knowledge of the to-be-learned regularities to enhance SL, as observed with the adult participants. These findings would also contribute to extend our knowledge of the mechanisms available to assist SL at each developmental stage. Although behavioral signs of learning, even under explicit conditions, were only observed for the adult participants, ERP data showed evidence of online segmentation in the brain in both groups, as indexed by modulations in the N100 and N400 components. A detailed analysis of the neural data suggests, however, that adults and children rely on different mechanisms to assist the extraction of word-like units from the continuous speech stream, hence supporting the view that SL with auditory linguistic materials changes through development. (shrink)

Research has indicated that microRNAs (miRNAs), a special class of non-coding RNAs (ncRNAs), can perform important roles in different biological and pathological processes. miRNAs’ functions are realized by regulating their respective target genes (targets). It is thus critical to identify and analyze miRNA-target interactions for a better understanding and delineation of miRNAs’ functions. However, conventional knowledge discovery and acquisition methods have many limitations. Fortunately, semantic technologies that are based on domain ontologies can render great assistance in this regard. In our (...) previous investigations, we developed a miRNA domain-specific application ontology, Ontology for MIcroRNA Target (OMIT), to provide the community with common data elements and data exchange standards in the miRNA research. This paper describes (1) our continuing efforts in the OMIT ontology development and (2) the application of the OMIT to enable a semantic approach for knowledge capture of miRNA-target interactions. (shrink)

In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...) domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. (shrink)

RESUMO Segundo Mikhail Bakhtin, a 'palavra monológica' não é realizada no diálogo; dela se depreende a 'palavra autoritária' que, como seu próprio nome indica, provém da autoridade, legal ou eclesiástica, do professor ou dos pais. Sua característica, como se escuta no discurso religioso, é a de não permitir a discussão; pede ser reconhecida e assimilada por nós. Entretanto, é possível que tal palavra, ainda que 'de outrem', seja convincente, incorporando-se ao nosso discurso com plena consciência; sendo assim, pode inclusive ser (...) considerada 'palavra dialógica'. Para explicá-la melhor, a 'palavra autoritária' será vinculada a enunciados dogmáticos próprios das religiões, como o judaísmo e o islã, e, sobretudo, do cristianismo católico.ABSTRACT According to Mihail Bakhtin, a 'monologic word' is not realized in dialogue; related to it, an 'authoritative word,' as its name implies, comes from authority, be it legal or ecclesiastical, from teachers or parents. As in religious discourse, it does not allow discussion; it asks to be recognized and assimilated. However, it may be that this word, coming from the 'discourse of the other,' is convincing, being incorporated into our discourse in full consciousness. Being so, it can even be considered a 'dialogical word.' To better explain it, the 'authoritative word' will be connected to dogmatic utterances of religions, such as Judaism or Islam, and especially the Catholic Christianity.RESUMEN Según Mijaíl Bajtín, la 'palabra monológica' es una que no está en diálogo; a ella se vincula la 'palabra autoritaria' que, como su nombre lo indica, proviene de la autoridad, sea legal o eclesial, del maestro, de los padres. Su característica, como se escucha en el discurso religioso, es que no permite la discusión; pide ser reconocida y asimilada por nosotros. Sin embargo, puede ser que dicha palabra, aunque sea 'ajena', resulte convincente y se incorpore a nuestro discurso con plena conciencia; siendo así, puede, incluso, ser considerada 'palabra dialógica'. Para explicarla mejor, la 'palabra autoritaria' será analizada con algunos enunciados dogmáticos, propios de las religiones, como el judaísmo o el islam y, sobre todo, del cristianismo católico. (shrink)

Cacao cultivation is one of the most important livelihoods for rural households in Colombia, where it is promoted as a substitute for the illegal cultivation of coca. To strengthen Colombian cacao farming, it is important to understand the livelihood strategies associated with cacao cultivation and the impact of these different strategies on the well-being of Colombian rural households. We analyzed the impact of cacao cultivation on the livelihood strategies and well-being of rural households in western Colombia. Research with 92 rural (...) cacao-growing households produced a typology of household livelihood strategies derived from their approach to cacao production. Indicators of each household capital and level of well-being were identified for each type of households. Correlations between the capitals and the capitals of greater importance in shaping the well-being of rural households were analyzed. Three types of rural households were identified: Cacao Farmers, Diversified Farmers with Cacao, and New Cacao Farmers. Cacao farmers have the highest capitals endowments and level of well-being, followed by Diversified Farmers with Cacao, and New Cacao Farmers. The conditions of cacao cultivation in rural households result in differentiated access to resources from capitals; households with better development of the crop have consolidated greater well-being where human capital has been its major driving factor. Success of the cacao crop and its relationship with well-being of rural households depends on the convergence of different capital resources. Thus, institutional efforts to strengthen the cacao sector in Colombia must go beyond investment to establish new hectares and consider aspects such as: Strengthening the skills and knowledge of producers to improve crop management practices, Promoting the participation of household members in associations, Stimulating sensitivity to the rooting and sustainable management of the crop, and Promoting processes of technification and adaptation of the infrastructure of fermenters and dryers, which will make it possible to guarantee an adequate quality of the cacao bean. (shrink)

This research presents an analysis of the learning strategies employed by students during confinement due to Covid-19 in the year 2021. The study sample consisted of 200 students from the Licenciado Benito Juárez García high school of the morning shift of the Benemérita Universidad Autónoma de Puebla. A survey was applied to measure the degree of satisfaction in relation to their use and impact on the acquisition of knowledge, allowing them to be more self-taught.The results show that the hypothesis was (...) partially fulfilled, since practice and organization are the learning strategies that most supported them in learning. (shrink)

The journey into the world of midwifery or nursing requires the student to attend to the intertwining of self-body-world in order to shift their knowledge of self-body-world into a client/patient-centered context. One of the teaching-learning strategies used to provide safe opportunities is the use of simulations and virtual practices. Rather than learning intimate acts of touching, or life and death decision-making in situations with actual clients/patients, students enter their learning world with rubber torsos, cloth babies, and cyber clinics. The “other” (...) is a simulated other, not a human. How does the student shift from seeing this simulated other as object to a sense of other as subject? In our world of constant use of technology for communication and entertainment, do students shift in and out of a cyber world easily or are they more captured by the simulated experience than with the human world? Has the human world redefined itself where the intertwining of self-body-world blurs the sense of where human body ends and cyber or simulated world begins? What is the place of Bildung when engaged with a cyber other? As a result of educational challenges, including rising enrolments, limited clinical placement opportunities, and increasing risk management concerns, there has been a proliferation in the use of simulation as a teaching strategy. This has left us –the authors– wondering about the student experience of simulation. What do they learn? How do they learn? How can this learning be applied in practice? (shrink)

Asperger's syndrome is a pervasive developmental condition characterized by features of autism. As observed in clinical practice, individuals with Asperger's syndrome present an impairment related to inflexibility in their everyday routine, an immediate manner of experiencing and relating, and difficulties in estimating periods of time. Following a phenomenological perspective, this study is an attempt to examine these aforementioned aspects in terms of temporality. Thirteen participants with Asperger's syndrome, from 13 to 20 years old, were interviewed about their experience of periods (...) of time, personal history, their past, present and future; and their concept of time and finitude. After the interviews, it was possible to identify three general themes which emerged in the invariant aspects of their experience of time: factual experience of present and future dimensions, chronological time and the past experience. Moreover, participants' descriptions evidenced aspects of experience based on the specificity of lived facts and a sense of time specifically related to what was lived in the past. (shrink)

Este trabajo trata de la importancia que tienen los estudiantes de medicina para responder a las demandas de atención médica en México; alude al proceso histórico que determina esta situación y la construcción de la categoría “médicos en formación”; refiere las condiciones laborales, educativas y de salud de los estudiantes de medicina en las unidades médicas, y su impacto sobre la calidad de la atención médica. Desde la perspectiva ética y de los derechos humanos se plantea que los programas de (...) educación médica, y en particular la categoría de “médicos en formación”, pueden, paradójicamente, violentar tanto el derecho a la educación como el derecho a la atención médica, y dañar tanto la salud de los estudiantes como la de la población por ellos atendida. Se concluye que debe desarrollarse un nuevo respaldo ético docente asistencial para educación médica en las unidades de atención médica. (shrink)

Resumen Nombrar implica ejercer el poder sobre lo nombrado, involucra coacción y coerción social. La atribución de nombres, adjetivos, designaciones, favorece la taxonomía cognitiva, pero también socio-ideológico-cultural. Cuando una Institución al servicio del Estado nomina, esas denominaciones tienen consecuencias en los sujetos nombrados. En México, a través de las prácticas semiótico- discursivas se llevó a cabo esta edificación del concepto de discapacidad con importantes implicaciones. El objetivo de este artículo es describir la construcción discursiva, a través de la historia de (...) la nominación de la discapacidad para vincular este hecho con el imaginario social de México y revisar las implicaciones socio-ideológicas resultantes. Para efectuar un primer acercamiento, estudiamos los términos con que se designa la discapacidad en los Censos de población y vivienda realizados por el organismo responsable y sustentamos la exposición del proceso a partir de las propuestas de Lyons y Serrano sobre las implicaciones semánticas vinculadas con la designación; de Thiebaut respecto a la articulación semántica del nombre con la pragmática del texto, y con apoyo en Koike para la co-construcción del significado. (shrink)

The need for education in moral values is increasingly being recognised today, but how is it to be conducted in schools? In particular we consider the appropriateness or otherwise of a teacher assuming the role of a neutral chairperson in discussion.Advocacy of such a stance is especially associated with Lawrence Stenhouse who saw neutrality as a procedural device in order to empower students’ own involvement. We point out many of the insights of Stenhouse's approach, but also some of its disadvantages (...) which subtly encourage a popularist form of relativism.We suggest the substitution of procedural neutrality with a different approach, that of critical affirmation. Here the teacher advocates a stance alongside everyone else. This, however, is done in a way that affirms pupils, and their right to personal views, whilst subjecting all views, including the teacher's own, to a close scrutiny, especially regarding implications for the views of others. (shrink)

Este artículo busca presentar una lectura posestructuralista sobre el Programa de Educación Ciudadana orientado a estudiantes de tercero medio que se implementa actualmente en Chile desde el 2021. Al respecto, pareciera que la educación cívica se entiende como una posible solución a las críticas expuestas en las revueltas estudiantiles que inician el 2006 y que se han mantenido hasta el día de hoy, el análisis del discurso permite indagar qué aspectos de la ciudadanía se buscan enseñar en la sala de (...) clases. La educación ciudadana ha sido históricamente implementada desde la creación del Estado chileno para abordar momentos de crisis, es por esto que la elaboración de programas nuevos podría vincularse a la necesidad de organizar una nación con problemáticas estructurales a nivel educativo. Se ha elegido realizar un análisis del discurso de los documentos curriculares a través de una perspectiva posestructuralista, porque se cree que este enfoque permite comprender los programas desde otros lugares, posibilitando la comprensión y el análisis crítico de las ideas que se encuentran en el objetivo de educar a la ciudadanía. (shrink)

The synthesis between death and vocation that has in the structure ‘being toward vocation’ its conclusion is the key to human finitude according to Ortega y Gasset. This means, against Heidegger’s ‘being toward death’, that in Ortega death, far from being understood as a priori horizon of meaning of existence and sign of human finitude, is an essential ingredient -and a posteriori- of human life which, together with the human vocation, essentially defines existence. The development of that synthesis obliges us (...) to explain two fundamental problems that form part of the essence of death. The first is the mystery of death, which is basically due to two questions: the enigmatic ceasing to be that describes death, and the particular fact that death is simultaneously exterior and interior to life, strange and familiar. The second problem is the question of why human beings do not want to die and want to live, a question substantially linked to the question of the meaning of human life. (shrink)

Summary The need for education in moral values is increasingly being recognised today, but how is it to be conducted in schools? In particular we consider the appropriateness or otherwise of a teacher assuming the role of a neutral chairperson in discussion. Advocacy of such a stance is especially associated with Lawrence Stenhouse who saw neutrality as a procedural device in order to empower students? own involvement. We point out many of the insights of Stenhouse's approach, but also some of (...) its disadvantages which subtly encourage a popularist form of relativism. We suggest the substitution of procedural neutrality with a different approach, that of critical affirmation. Here the teacher advocates a stance alongside everyone else. This, however, is done in a way that affirms pupils, and their right to personal views, whilst subjecting all views, including the teacher's own, to a close scrutiny, especially regarding implications for the views of others. (shrink)

El objetivo marcado en este trabajo es establecer una línea de continuidad entre el pensamiento de Ortega y el de María Zambrano, situando a ambos en un contexto común de crítica a ciertos excesos de la Modernidad. Así, la propuesta se basa en un análisis de la racionalidad científico-matemática como ámbito excluyente de ciertos planos de la realidad, y en cómo ambos autores son conscientes de ello (aunque lo manifiesten desde distintos prismas y atendiendo a diferentes asuntos). De esta manera, (...) se pretende mostrar que la comprensión orteguiana del _concepto_ en tanto que instrumento de captación parcial de la realidad se vincula al modo en que Zambrano comprende la existencia, función y generación de los dioses, siendo tanto aquél (el _concepto_) como éstos (los dioses) formas de enmascarar la realidad para su humana interpretación. Asimismo, el trabajo pretende mostrar cómo, frente a la razón del racionalismo occidental, caben formas de conocimiento que trascienden el mero pensar conceptual, tales como el arte. (shrink)

The aim of this paper is to identify, given certain democratic normative standards regarding deliberation, some pros as well as cons of possible online deliberation designs due to variations in two key design dimensions: namely, asynchronicity and anonymity. In particular, we consider one crucial aspect of deliberative argumentation: namely, its reciprocity, which puts interaction centre stage to capture the back-and-forth of reasons. More precisely, we focus on two essential features of the deliberative interaction: namely, its listening widely and listening carefully. (...) We conclude that one sort of online deliberation that combines the two design features of anonymity and asynchronicity is likely to better promote the reciprocity required for democratic deliberation than both natural and designed offline deliberations and online simulations of them. (shrink)